X3 is locking up in Vista x64

Hi all,

I am suddenly having a problem with the CDx3 locking up in my Vista Ultimate 
x64.  I have had it installed for months and it has worked just fine, and 
suddenly it has started to lockup whenever I try to open a cdr file.  It 
will totally lock up, nothing works, I can't close it from within the 
program or even with the Task Manager.  Ctr;=Alt-Del does not work.  The 
only thing I can do is to reboot the machine.  I get no error messages, 
nothing.  I have tried this with several different files so it is not just 
one that may be corrupted as I had originally thought.

Has anyone else seen this kind of thing, or have any suggestions how I might 
troubleshoot it?

 Jan :)